Vyvanse side effects | lisdexamfetamine side effects

Vyvanse side effects | lisdexamfetamine side effects

 

vyvanse side effects. Vyvanse (active ingredient: lisdexamfetamine dimesylate) is a brand-name prescription drug that treats attention deficit hyperactivity disorder (ADHD) in adults and children older than 6 years.
It’s also approved for binge-eating disorder (BED) in adults but is typically used as a second-line therapy.

Vyvanse belongs to a class of central nervous system stimulants called amphetamines. Its primary effect is to speed up the brain.
Unlike most other stimulant medications, Vyvanse is a prodrug, which means it has no effect until it’s metabolized by the body into its active form, dextroamphetamine.
Like all stimulant medications, Vyvanse may not be right for everyone. Side effects, warnings, and drug interactions need to be discussed with a doctor before starting this medication.

When taken for ADHD, the most common side effects of Vyvanse are:

Decreased appetite
Loss of appetite
Weight loss
Diarrhea
Nausea
Vomiting
Upper stomach pain
Dry mouth
Dizziness
Insomnia
Irritability
Anxiety

Serious side effects of Vyvanse – vyvanse side effects

All medications that alter the central nervous system can produce serious and even life-threatening side effects. Many severe side effects of Vyvanse are related to its effects on speeding up the brain and the nervous system.

The most serious side effects of Vyvanse include:

Psychiatric problems such as anxiety, aggression, or mania
Neurological disorders such as tics, seizures, or serotonin syndrome
Heart problems such as rapid heartbeat, heart attack, and sudden death in people with heart problems
Circulation problems such as high blood pressure, stroke, peripheral blood vessel damage, skin color changes, and Raynaud’s phenomenon
Severe allergic reactions
Dependence, drug abuse, and withdrawal symptoms if discontinued abruptly

 

Weight loss – vyvanse side effects

Two pronounced side effects of Vyvanse are decreased appetite and weight loss. While decreased appetite is equally common among adults and children, weight loss is a more common side effect of Vyvanse in children. In the initial clinical trials of Vyvanse, almost 1 in 10 children taking Vyvanse for four weeks lost weight in proportion to the dose: the larger the dose, the greater the average amount of weight was lost. Children on Vyvanse also exhibit slower growth than other children.

Only 3% of adults taking Vyvanse for ADHD lost weight in a similar four-week period. However, when Vyvanse is taken for binge eating disorder, weight loss was experienced in 4% of patients. Later studies show that a clinically significant number of people with binge eating disorder lose weight when taking Vyvanse by reducing appetite and the number of binge eating episodes each week.

Because lowered appetite and weight loss are side effects of Vyvanse, some physicians prescribe Vyvanse off-label for severe obesity in children and adolescents.

Anxiety
In previous studies, 5% to 6% of adults report anxiety as a side effect of Vyvanse. Children experience anxiety as a Vyvanse side effect less often. In one study, anxiety and agitation was reported in less than 1% of children.

Normally, stimulants such as Vyvanse speed up and excite the brain, so alertness, energy, nervousness, restlessness, agitation, racing thoughts, and anxiety are common side effects. However, in people with ADHD, certain stimulants increase alertness, attention, and impulse control while reducing hyperactivity, anxiety, and restlessness. These stimulants increase certain chemicals in the brain—dopamine and norepinephrine. Because patients with ADHD do not produce enough of these chemicals, stimulants improve their ability to manage hyperactivity and attention.

Too much dopamine and norepinephrine, a chemical similar to adrenaline, overexcites the brain and causes high energy, inattention, nervousness, agitation, excitability, or euphoria. If a person with normal levels of dopamine and norepinephrine is experiencing anxiety, Vyvanse will probably worsen the anxiety. Side effects such as anxiety, jitteriness, and tension may be indications that either Vyvanse or the dose prescribed is inappropriate.

Withdrawal – vyvanse side effects

Vyvanse is a Schedule II controlled substance, meaning it has a high potential for abuse and dependence. When used over a long period, Vyvanse can cause withdrawal symptoms if the dose is reduced or the drug is suddenly discontinued. These symptoms include:

Fatigue
Excessive sleeping
Depression
Mood swings
Increased appetite
Cravings
Most Vyvanse withdrawal symptoms resolve in five to seven days. The prescribing physician may use a tapering dose to prevent or reduce withdrawal symptoms. There are certain side effects such as serotonin syndrome or heart problems that will require that Vyvanse be immediately discontinued.

Vyvanse should never be taken within at least 14 days of taking monoamine oxidase inhibitors (MAOIs), including certain types of antidepressants, antibiotics, and Parkinson’s medications such as:

Tranylcypromine
Marplan (isocarboxazid)
Nardil (phenelzine)
Linezolid
Selegiline
Xadago (safinamide)
Methylene blue injection
In combination with Vyvanse, the effects of these drugs can cause dangerously high blood pressure.

Stimulants
Vyvanse can enhance the effects of other CNS stimulants, including increased blood pressure and heart rate. CNS stimulants include:

Caffeine, cocaine, or ginseng
Other ADHD medications
Certain nasal decongestants
Appetite suppressants such as phendimetrazine
Wakefulness agents that treat narcolepsy
Steroids
Sympathomimetic medications such as epinephrine or norepinephrine
Depressants
In general, combining stimulants with depressants is rarely advisable. Amphetamines such as Vyvanse usually blunt the effects of depressants, but some combinations of amphetamines and depressants can be hazardous. Vyvanse should not be used with depressants such as:

Alcohol, marijuana, or cannabinoids
Cough medications
Narcotics
Sedatives
Barbiturates
Anxiety medications
Nerve pain drugs
Anti-nausea drugs
Anticonvulsants
Some Parkinson’s disease medications
Antidepressants and serotonergic medications
Unless deemed safe by a healthcare provider, do not use Vyvanse in combination with any other drug that alters levels of serotonin. Antidepressants, some migraine medications, and certain appetite suppressants taken in combination with Vyvanse increase the risk of serotonin syndrome.

Blood pressure medications
Amphetamines such as Vyvanse raise blood pressure, so they block the effects of medications intended to lower blood pressure. Combining amphetamines with blood pressure medications will require close monitoring and possibly therapy modification. Amphetamines are also avoided in combination with medications that raise blood pressure.

Acidifying or alkylating agents
Drugs that increase (acidify) or decrease (alkylate) the acid content in the stomach or urine will reduce the body’s ability to absorb Vyvanse and interfere with the ability to eliminate Vyvanse. In particular, when taking Vyvanse, avoid antacids, acidic foods, citrates, and diuretics. Certain multivitamins should also be avoided.

Ask a healthcare professional for a complete list of drug and food interactions.

How to avoid Vyvanse side effects – vyvanse side effects

Stimulants such as Vyvanse commonly cause side effects. Because Vyvanse speeds up the brain, it’s not uncommon to experience side effects such as decreased appetite, insomnia, elevated blood pressure, fast heart rate, agitation, or restlessness. Some patients experience a “Vyvanse crash” similar to withdrawal when the drug wears off later in the day.

A few tips can help manage Vyvanse side effects:

Take Vyvanse as directed. Don’t increase or decrease the dose. If the medicine does not seem to be working or side effects occur, talk to the prescribing physician about changing the dose or switching to a new medication. Always follow instructions on the medication guide.
Take Vyvanse at the same time each morning. Vyvanse should be taken early in the morning. Pick a time that is at least one hour before alertness and focus is required and stick to that schedule. If you miss a dose, take it later in the morning. However, avoid taking a dose in the afternoon to avoid sleeplessness at bedtime.
Disclose all of your medical conditions and medications. This will prevent side effects and dangerous interactions from occurring.
Find a coffee alternative. Other stimulants may increase the risk and severity of Vyvanse side effects, so it’s a good idea to avoid them. In addition to certain medications, stimulants also include caffeine. You may need to find an alternative pick-me-up to your daily cup of coffee.
Practice good sleep hygiene. Difficulty sleeping is one of the most common side effects of Vyvanse. The first step in overcoming medication-induced sleeplessness is to practice good, daily sleep hygiene practices. Avoid TV or video games before bedtime, develop a nighttime relaxation routine, and go to bed at the same time every night.
Take a medication holiday (if approved by your doctor). If side effects are a problem when taking ADHD stimulants, the prescribing doctor may suggest taking a “medication holiday” where the medication is discontinued or the dose reduced for a few days, weeks, or even months.
Taking a medication holiday, however, is not for everyone. Patients with moderate to severe ADHD symptoms may need to keep to a rigorous dosing schedule. Taking a medication holiday for binge eating disorder will raise the risk of severe binge eating. Seek professional medical advice first; there may be alternative therapies with fewer side effects.

 

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